MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Identifieur interne : 000025 ( Main/Exploration ); précédent : 000024; suivant : 000026MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Auteurs : Wissem Deraredj Nadim ; Viorel Simion ; Helene Benedetti ; Chantal Pichon ; Patrick Baril ; Severine Morisset-Lopez [France]Source :
- Current neuropharmacology [ 1875-6190 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Antagomirs (pharmacology), Antagomirs (therapeutic use), Cognition Disorders (drug therapy), Cognition Disorders (genetics), Databases, Bibliographic (statistics & numerical data), Gene Expression Regulation (drug effects), Gene Expression Regulation (physiology), Humans, MicroRNAs (antagonists & inhibitors), MicroRNAs (genetics), MicroRNAs (metabolism), Neurodegenerative Diseases (drug therapy), Neuronal Plasticity (drug effects), Signal Transduction (drug effects).
- MESH :
- chemical , antagonists & inhibitors : MicroRNAs.
- chemical , genetics : MicroRNAs.
- chemical , metabolism : MicroRNAs.
- chemical , pharmacology : Antagomirs.
- chemical , therapeutic use : Antagomirs.
- drug effects : Gene Expression Regulation, Neuronal Plasticity, Signal Transduction.
- drug therapy : Cognition Disorders, Neurodegenerative Diseases.
- genetics : Cognition Disorders.
- physiology : Gene Expression Regulation.
- statistics & numerical data : Databases, Bibliographic.
- Animals, Humans.
Abstract
Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.
PubMed: 27396304
Affiliations:
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Le document en format XML
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uniqKey="Morisset Lopez S" first="Severine" last="Morisset-Lopez">Severine Morisset-Lopez</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Orleans</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27396304</idno><idno type="pmid">27396304</idno><idno type="wicri:Area/PubMed/Corpus">000027</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000027</idno><idno 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uniqKey="Simion V" first="Viorel" last="Simion">Viorel Simion</name></author><author><name sortKey="Benedetti, Helene" sort="Benedetti, Helene" uniqKey="Benedetti H" first="Helene" last="Benedetti">Helene Benedetti</name></author><author><name sortKey="Pichon, Chantal" sort="Pichon, Chantal" uniqKey="Pichon C" first="Chantal" last="Pichon">Chantal Pichon</name></author><author><name sortKey="Baril, Patrick" sort="Baril, Patrick" uniqKey="Baril P" first="Patrick" last="Baril">Patrick Baril</name></author><author><name sortKey="Morisset Lopez, Severine" sort="Morisset Lopez, Severine" uniqKey="Morisset Lopez S" first="Severine" last="Morisset-Lopez">Severine Morisset-Lopez</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Biophysique Moleculaire, CNRS UPR4301, Universite d'Orleans France, 45071 Orleans Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Orleans</settlement></placeName></affiliation></author></analytic><series><title level="j">Current neuropharmacology</title><idno type="eISSN">1875-6190</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antagomirs (pharmacology)</term><term>Antagomirs (therapeutic use)</term><term>Cognition Disorders (drug therapy)</term><term>Cognition Disorders (genetics)</term><term>Databases, Bibliographic (statistics & numerical data)</term><term>Gene Expression Regulation (drug effects)</term><term>Gene Expression Regulation (physiology)</term><term>Humans</term><term>MicroRNAs (antagonists & inhibitors)</term><term>MicroRNAs (genetics)</term><term>MicroRNAs (metabolism)</term><term>Neurodegenerative Diseases (drug therapy)</term><term>Neuronal Plasticity (drug effects)</term><term>Signal Transduction (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antagomirs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antagomirs</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term><term>Neuronal Plasticity</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cognition Disorders</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Bibliographic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Centre-Val de Loire</li><li>Région Centre</li></region><settlement><li>Orleans</li></settlement></list><tree><noCountry><name sortKey="Baril, Patrick" sort="Baril, Patrick" uniqKey="Baril P" first="Patrick" last="Baril">Patrick Baril</name><name sortKey="Benedetti, Helene" sort="Benedetti, Helene" uniqKey="Benedetti H" first="Helene" last="Benedetti">Helene Benedetti</name><name sortKey="Nadim, Wissem Deraredj" sort="Nadim, Wissem Deraredj" uniqKey="Nadim W" first="Wissem Deraredj" last="Nadim">Wissem Deraredj Nadim</name><name sortKey="Pichon, Chantal" sort="Pichon, Chantal" uniqKey="Pichon C" first="Chantal" last="Pichon">Chantal Pichon</name><name sortKey="Simion, Viorel" sort="Simion, Viorel" uniqKey="Simion V" first="Viorel" last="Simion">Viorel Simion</name></noCountry><country name="France"><region name="Centre-Val de Loire"><name sortKey="Morisset Lopez, Severine" sort="Morisset Lopez, Severine" uniqKey="Morisset Lopez S" first="Severine" last="Morisset-Lopez">Severine Morisset-Lopez</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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